generegulation相关论文
How distinct transcriptional programs are enacted to generate cellular heterogeneity and plasticity,and enable complex f......
Our goal is to decipher which DNA sequences are required for tissue-specific expression of epididymal genes. At least 6 ......
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Peroxisome proliferator-activated receptor gamma regulates fatty acid binding protein(FABP3)gene exp
Peroxisome proliferator-activated receptor gamma (PPARG),a key transcription factor involved in lipid metabolism,affects......
Nucleotide-binding site leucine-rich repeat (NB-LRR) proteins in plants constitute a large family and play very importan......
Purpose To explore the expression of microRNA in Eaf2 knockout mouse,and the effect of Eaf2 on both human lens epithelia......
Computational analysis and prediction of miRNA-based pharmacogenomics on anti-cancer small molecules
In last decade,the “one drug,one gene,one disease” paradigm limited the development of new drugs,thus growing pharmaco......
Background: The piRNA machinery is well known for its role in mediating epigenetic silencing of transposons and recent s......
Gene module based regulator inference identifying miR-139 as a tumor suppressor in colorectal cancer
Colorectal cancer is one of the most commonly diagnosed cancer types worldwide.Identifications of the key regulators of ......
A multicell model for enhancer prediction based on AdaBoost algorithm and shape features of chromati
Background: Accurate identification of DNA regulatory elements has become an urgent need in the post-genomic era.Recentl......
In the thesis,we synthesized three 20mer caged circular asODNs(R20,R20B2 and R20B4) with a photocleavable linker and an ......
Background: Tremendous amounts of omics data being accumulated poses a pressing challenge of meta-analyzing these hetero......
A complete set of new phospate-caged photolabile nucleoside phosphoramidites were synthesized,and were then site-specifi......
Ultra-Small Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nucl
Nanoscale materials have been catching growing attention in the field of biomedicine.Understanding of the behavior of na......
PGE2 stimulates aromatase expression via MAPK-mediated activation of ATF2 and c-Jun in human endomet
Background Endometriosis is an estrogen-dependent disease, and aromatase is the key enzyme for estrogen biosynthesis.Ele......
Relation and regulatory mechanism between the concentration of Imatinib in bone marrow cells and the
Objective: To determine the relationship of Imatinib (IM) concentration in bone marrow and its therapeutic response in p......
Increased Expression of EIF5A2,via Hypoxia or Gene Amplification,Contributes to Metastasis and Angio
Background & Aims: Solid tumors often become hypoxic,leading to activation of hypoxia-response genes.We investigated the......
Mitogen-activated protein kinase kinase4 deficiency in cardiomyocytes causes connexin 43 reduction a
Connexin 43 (Cx43) is the predominant isoform of gap junction proteins in the working myocardium.In the heart, mitogen-a......
Tetracycline-regulated HSV-1 vector delivery of the LacZ gene into dorsal root ganglion via the scia
The epidemiological studies of peripheral nerve injuries (PNIs) have shown that the incidence of PNIs may vary according......
The role of upstream stimulatory factor 1 in the transcriptional regulation of the human TBX21 promo
T-bet is a key regulator for the lineage commitment in CD4+ T helper (Th) 1 cells by activating the hallmark production ......
Antisense oligonucleotide modulation of gene expression:A RNA-silencing process regulated by biomime
RNA interference(RNAi)is an siRNA-dependent gene silencing approach controlled by an RNA-induced silencing complex(RISC)......
Effect of trans-acting factor on rat glutathione S-transferase P1 gene transcription regulation in t
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Testicular germ cell tumors type 2 have high RNA expression of LDHB,the gene for lactate dehydrogena
This study analyzed RNA expression of genes for three serum tumor markers,alpha fetoprotein(AFP),human chorionic gonadot......
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Cellular senescence refers to an irreversible cell-cycle arrest program that cell permanently loses proliferative po......
The Arabidopsis polyamine transporter LHR1PUT3 modulates heat responsive gene expression by regulati
Polyamines involve in gene regulation by interacting with and modulating the functions of various anionic macromolec......
Residing in the physical heart of the cell,the nucleus has now fully shed its once one-dimensional reputation as the......
Gene regulation is central for plant adaptation to environment.Many plant genes are repressed and are kept inactive ......
编码病毒的 microRNAs ( miRNAs )是 miRNAs 的一种新类型通过导致 mRNA 的劈开在主机房间或病毒调整目标基因的表达式，镇压翻译，等......
肝癌是最常见的恶性肿瘤之一，其在中国的发病率及死亡率均高，严重危害着人们的健康，它的发生发展是由多因素影响的。目前肝癌形成过程......
核糖开关是一类自然界中天然存在的适配子，通过结合小分子代谢物调控基因的表达。它位于特定的mRNA非编码区，可以不依赖任何蛋白质因......
先前曾报告鸡ＡＣｈＲγ亚基基因５连接区－５３８／－２８８片段（含一对Ｅ盒子）与生肌调节因子（ｍｙｏｇｅｎｉｎ）的相互作用，为进一步观察ＤＮＡ－ｍｙｏｇｅｎｉｎ相互作用对γ基因转录激活功能的影响，利用瞬时......
Skeletal muscle fitness plays vital roles in human health and disease and is determined by developmental as well as phys......
Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone
In rodents, well characterized neurogenic niches of the adult brain, such as the subventricular zone of the lateral vent......
在高等生物个体的发育和生长过程中,细胞通过调控细胞核内染色质高级结构的动态变化来有选择性地进行基因的激活和沉默,从而控制细......
会议
Pioneer transcription factors(TFs)are a special category of TFs with the capacity to bind to closed chro-matin regions i......
微小RNA(miRNA)是一类进化保守、长度为19～ 25 nt的短序列非编码单链小RNA分子,它的发现揭示了一种新的基因表达调控方式.它们通过......
随着人类基因组计划的完成,整个人类基因的转录图谱已绘出.然而,蛋白编码基因以外的、特别是和人类疾病有关的基因的转录程度和功......
浦肯野纤维是心脏传导系统的最后分支,在心内膜下交织成网,再通过特殊的连接方式与普通心室肌细胞相连,主要功能是迅速将电活动传......
酪氨酸激酶下游蛋白（ DOK）在受体酪氨酸激酶介导的信号通路中起着重要的调节作用。DOK蛋白参与细胞生命活动相关的多种信号通路的调......
The paper presented an implement method for a dynamic gene expression display software based on the GTK. This method est......
心肌纤维化是心肌正常组织结构中出现的以成纤维细胞增殖、胶原过度沉积及异常分布为主要表现的病变。微小核糖核酸（miRNAs）是一类内......
AIM: To investigate the role of genes and kinetics of specific transcription factors in liver regeneration, and to analy......
The antisense transcript long non-coding RNA (1ncRNA) (antisense non-coding RNA in the INK4 locus,ANRIL) is an antisense......
肺癌是世界范围内最常见的恶性肿瘤之一,5年生存率极低,已成为我国肿瘤中的第一位死因。 microRNA ( miRNA）是小分子非编码RNA ( Ri......
Revealing localization and regulation of GTPase PmRab7 in lymphoid cells ofPenaeus monodon after WSS
本文通过对荣华二采区10...
In eukaryotic genome biology,the genomic organization inside the three-dimensional(3D)nucleus is highly complex,and whet......
Nucleosomal Context of Binding Sites Influences Transcription Factor Binding Affinity and Gene Regul
Transcription factor (TF) binding to its DNA target site plays an essential role in gene regulation.The location,orienta......
目的 研究急性单核细胞白血病细胞系THP-1细胞MLL-AF9融合基因沉默对p27表达及转录调控的影响.方法 选择THP-1细胞特有的MLL-AF9融......
目的 探讨NF-κB结合位点在NOD2基因调控中的作用.方法 以人基因组DNA为模板,PCR扩增含有NF-κB结合位点的人NOD2基因启动子序列,......
